Mumbai: The Indian Institute of Technology-Delhi has developed a wide array of software tools for drug designing and developing individualised medicine.
"The ChemGenome software will be useful for genome analysis and Bhageerath will help in predicting protein structure," said B Jayaram of IIT-Delhi's Supercomputing Facility for Bio-informatics and Computational Biology.
The department has also developed a DNA-protein directed lead molecule design protocol called Sanjivini, he told a three-day international symposium on "Emerging trends in genomic and proteomic sciences" that concluded on Wednesday.
The ChemGenome software can distinguish genes from non- genes in 331 bacterial genomes and 20 eukaryotic genomes with almost 90 per cent accuracy.
The protein structure prediction software can successfully bracket native-like structures in the lowest energy structures for 50 small alpha helical and mixed globular proteins, Jayaram said.
"The drug design protocols could sort out marketed drugs from non-drugs for some known drug targets," he said.
He also pointed out that currently, without the help of any database, an inspection of a DNA sequence does not tell whether it is likely to be a gene. If it is a gene, such an inspection does not reveal the likely three-dimensional structure of its protein product.
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